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| Application of Synchronous and Radiotherapy in Patients with Esophageal Carcinoma |
| The People’s Hospital of Dongguan， Dongguan 523000，China |
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Abstract Objective：To study clinical therapeutic effect of the simultaneous and sequential chemoradiotherapy in patients with esophageal carcinoma and safety，to find the best method of treatment of esophageal cancer，reduce the recurrence rate，improve the survival rate of cancer.Method：100 patients with esophageal cancer in our hospital from June 2011 to June 2014 selected the cases admitted as the clinical research object，randomly divided into two groups，the control group were treated with radiotherapy，namely in the two course of chemotherapy，radiotherapy；the test group was treated with concurrent chemoradiotherapy treatment at the same time，namely the chemotherapy and radiotherapy on the first day of treatment，were compared after treatment，compared to patients with clinical curative effect， and adverse reactions during the treatment of the contrast and analysis of the detailed record， after discharge for a period of three years of follow-up for all patients participating in this experiment.Result：The test group with concurrent chemoradiotherapy treatment markedly 20 cases，effective 28 cases，invalid 2 cases，the total effective was 96.00%，the control group used sequential chemoradiotherapy for treatment of 15 cases markedly effective， effective 20 cases， invalid 15 cases， the total
effective was 70.00%， the difference between the two groups was statistically significant（P<0.05）.The rate of adverse reactions occurred in test group 56.00%，control group of adverse reaction in 50.00%，differences between the two groups was not statistically significant（P>0.05）.Conclusion：Using the clinical effect of concurrent chemoradiotherapy in the treatment of esophageal carcinoma is more obvious， adverse reactions during treatment was higher than that of sequential chemoradiotherapy，but adverse reactions were in the range of patients can bear，serious consequences， not the whole process is safe and reliable，patients and family members of patients more satisfied，so it is worthy for us to continue to explore and wide in the clinical application.
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