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| The Efficacy of the Combined Raltitrexed Plus Oxaliplatin and in the Treatment of Senile Advanced Colorectal Carcinoma |
| Tongling People’s Hospital， Tongling 244000， China |
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Abstract Objective： To observe the efficacy of the combined raltitrexed plus oxalplatin in the treatment of senile advanced colorectal carcinoma. Method： Thirty-nine advanced colorectal cancer patients were divided into two groups. The treatment group（ n=20） was administered intravenously raltitrexed plus oxaliplatin regimen. The control group （n=19） was administered S1 plus Oxaliplatin regimen. Result： All the patients in the treatment group and control group were evaluated. Effective rate of the treatment group and control group was 60.00% and 26.32%， respectively. Median TTP was 8.1 and 4.9 months， respectively. The significant statistical difference was found in the short-term efficacies of the two groups（ P<0.05）. Adverse reactions compared to the elevated transaminase enzymes of the treatment group was higher than that of the control group. There were more patients who reduced neutropenia in the treatment group（ P<0.05）. There were more patients who developed vomiting in the control group（ P<0.05）. Conclusion： The raltitrexed plus oxaliplatin regimen is effective and safe in senile patients with advanced colorectal carcinoma， which is worthy of clinical popularization and application.
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