Objective： To discuss the effect of fortified nutrition on facilitating wound healing of patients in endoscopic therapy for cirrhosis and esophageal varices. Method： 136 patients in endoscopic therapy for cirrhosis and esophageal varices were randomly divided into two groups. The control group was adopted the way of normal therapy. The treatment group was adopted the way of intervention of fortified nutrition on that basis. Result： After the treatment， the whole effective rate of wound healing in the treatment group was 97.06%， evidently higher than that of 83.82% in the control group. In addition， the treatment group was better than the control group in the respect of the plasma albumin and prothrombin time. In the treatment group， there were 28 patients with visible injection site anabrosis， which was obviously less than the 52 patients in the control group. There were 15 patients with slight bleeding on injection site anabrosis in the control group， which was obviously more than the 2 patients in the treatment group. The difference between the two groups was statistically significant（ P<0.05）. Conclusion： Adopting the intervention of fortified nutrition on patients in endoscopic therapy for cirrhosis and esophageal varices can effectively accelerate the speed of wound healing and improve liver functions.