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Abstract Objective： To discuss the curative effect of the operation which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large）. Method： The operation clinical data which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large） of 46 cases were reviewed. Result： There were 46 cases of the operation which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large） were successful simultaneous therapy， the success rate of lithotomy was 100%. Operation time was 60-155 min， average（ 90.54±19.75） min. The bleeding was 50-300 mL， average（150.42±55.46）mL. The patients were in hospital 7-9 days， average（ 7.53±0.68）days after operation. No patient dead in operation or hemorrhage or blood transfusion or bladder perforation or（ TURS） or urinary fistula or infection of incision complications. The time follow-up was 6-24 months， average（ 16.76±5.11）months， IPSS， QOL， PVR was improved before operation， a statistically significant difference（ P<0.05）， IPSS from preoperative average（ 26.48±2.54） points to（ 5.63±1.22） points， QOL from preoperative average（ 4.63±1.12） points to（ 1.23±0.94） points， PVR from preoperative average（ 208.38±35.53）mL to（ 13.52±3.47）mL. All patients were urinate unobstructed with no really urinate incontinence or no bladder calculi recurrence or urethral stricture. Conclusion： TUPKEP combined with bladder lithotomy for benign prostatic hyperplasia with bladder multiple calculi（ large） simultaneous therapy is safety and simple method with good effect and little trauma，especially fit for the patients which aged high-risk with larger bladder prostate and multiple stones and other basis of disease.
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