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| Serum Level of Carcinoembryonic Antigen and Whole-body Metastasis Ability Risk Assessment in Patients with Advanced Non-small Cell Lung Cancer |
| The Selond Affiliated Hospital of Henan University of Science and Technology，Luoyang 471000，China |
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Abstract Objective： To study the serum level of carcinoembryonic antigen and whole-body metastasis ability risk in patients with advanced non-small cell lung cancer，and provide the reference for clinical.Method： 160 patients with stage IV NSCLC in our hospital from March 2012 to January 2014 were selected. Research indicators included age，height，weight，age，sex，histological classification，tumor differentiation ，CEA level，smoking status，bone metastases，lymphatic metastasis，obstinate/transfer， transfer， soft tissue of neck metastases， brain metastases， systemic metastasis score and systemic metastasis LN-adjustment score， and the statistical analysis was performed. Result： The sex，bone metastases，histological classification lymph node metastasis and brain metastasis of different CEA level patients had ad statistical significance（ P<0.05），but the age， smoking status， tumor differentiation，obstinate/transfer，transfer， and soft tissue of neck metastases showed no statistical difference（P>0.05）.Serum CEA level increased from 2.7 ng/mL in LN-adjusted whole-body metastatic score 1 to 374.1 ng/mL in LN-adjusted whole-body metastatic score 7，the difference was statistically significant（ P=0.003）.Similarly， the low LN-adjusted whole-body metastatic score （rating 1-3） showed CEA level significantly reduced when compared with adjustment of high LN-adjusted whole-body metastatic score（ rating 4-7），the difference was statistically significant（P<0.001）.Scores of high CEA levels in serum from 37.5%（15/40） in LN-adjusted whole-body metastatic score 1 rose to 100%（1/1） in LN-adjusted whole-body metastatic score 6， the difference was statistically significant（P<0.001）.Similarly， high serum CEA score rose from 25%（ 2/8） in LN-adjusted whole-body metastatic score 1 rose to 100%（1/1） in LN-adjusted whole-body metastatic score 7， the difference was statistically significant（P<0.001）.Univariate analysis results showed that gender， bone metastases， histological classification and lymph node metastases and brain metastasis were risk factors of high CEA level，multivariate Logistic regression analyses showed that the histological classification OR（95% CI）=3.611（1.375-5.313）（P<0.001），bone metastases OR（95% CI）=3.513（1.856-4.637）（P<0.001），and brain metastases OR（95% CI）=3.338（1.271-5.533）（P<0.001）were independent risk factor of the influence of high CEA level. Conclusion： High serum CEA level and systemic metastasis increases with advanced non-small cell lung cancer are closely related. High serum
CEA level is more frequently in bone metastases， brain metastasis， lymph node metastasis and lung metastasis patients.
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