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Abstract Objective：To evaluate the effect of simulate Problem-based learning（ PBL） teaching model combine with Role-playing method in the history-taking practices of diagnostics.Method：97 students of grade 2012 clinical medicine specialty of Zunyi medical college were randomly selected.The traditional teaching model +standardized patient （SP） teaching method， simulate PBL teaching model + Role-playing method were applied in the history-taking practices teaching of all students successively， each method practice periods are for 4 hours.Two kinds of teaching methods effect was evaluated according to the results of history-taking skills test score and feelings of students after history-taking practices.Result：The score of history-taking skills test in the simulate PBL teaching model +Role-playing method were higher than traditional teaching model + SP teaching method group（P< 0.05）， more than 90% of the students feel that the simulate PBL teaching model +Role-playing method was applied to history-taking practices teaching was more interested in learning， the classroom atmosphere more active，was satisfied with the teaching effect， was beneficial to the improvement of doctor-patient communication skills.Conclusion：Simulate PBL teaching mode + role-playing teaching method apply to history-taking practices teaching can mobilize students’ learning enthusiasm， is a good way to cultivate students communication skills.
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