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Abstract Objective：To evaluate the curative effect and safety of paroxetine with cognitive behavior therapy. Method：60 obsessive-compulsive disorder patients with Yale-Brown obsessive-sive-compulisive scale（ Y-Bocs） score ≥16 were randomly divided into study group（ treated with paroxetine and cognitive behavior therapy for 5 months） and control group （treated with paroxetine for 5 months），clinical effect was assessed with Yale-Brown obsessive-compulisive scale（ Y-Bocs）and treatment emergent symptom scale（ TESS），month 1，2，3，4 and 5.Result：Compared with the control group，the study group showed more Y-Bocs score decrease，although both groups Y-Bocs score decreased after treatment.The side effects of the two groups were fewer and lighter. Conclusion：Paroxetine with cognitive behavior therapy demonstrates more treatment effects than paroxetine only for patients with obsessive-compulsive disorder（ OCD）.
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