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| The Changes and Significance of Cytokines IL-6，IFN-γ，TNF-α in the Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Tuberculosis |
| Inner Mongolia People’s Hospital，Hohhot 010017，China |
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Abstract Objective：To investigate the change and significance of cytokines IL-6，IFN-γ，TNF-α in the patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis.Method：The serum levels of cytokines IL-6，IFN-γ，TNF-α in the patients with COPD complicated with TB were measured by double antibody sandwich enzyme-linked immunosorbent assay（ELISA），whose patients were including 152 patients with COPD complicated by pulmonary tuberculosis（COPD and TB group），150 patients with pulmonary tuberculosis （TB group），as well as 157 patients with COPD（COPD group） and 50 healthy volunteers（ healthy control group） in the department of respiratory medicine of our hospital from March 2011 to December 2013 were selected.The data were analyzed by SPSS 13.0 statistic software.Result：Compared to the healthy control group，the serum levels of cytokines IL-6，IFN-γ，TNF-α in the patients with COPD complicated with TB and TB group were increased，the differences were statistically significant（P<0.05）.Compared to the COPD and TB group，the serum levels of cytokines IL-6，IFN-γ，TNF-α in the patients with COPD complicated with TB group were increased，the differences were statistically significant（P<0.05），however，there were no statistically significant differences in the serum levels of cytokines IL-6，IFN-γ，TNF-α between the patients with COPD and TB group（P>0.05）.Conclusion：There are different extents of imbalance of some serum cytokines IL-6，IFN-γ，TNF-α in the patients with COPD complicated by TB.It suggests that there are important roles of these cytokines in immune pathogenesis of COPD complicated with TB and will provide theoretical evidence to immune intervention.
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