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| The Clinical Significance of Early Identification of Severe Hand Foot and Mouth Disease by the Serum Levels of S-100βProtein Combined with Cranial Magnetic Resonance |
| Ganzhou Maternal and Chilid Health Hospital，Ganzhou 341000，China |
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Abstract Objective：To investigate the clinical significance of early identification of severe hand foot and mouth disease（ HFMD） and its prognosis by the serum levels of S-100β protein combined with cranial magnetic resonance. Method：50 cases diagnosed with HFMD were collected from the women’s and children’s hospital of Ganzhou from May 2013 to May 2014. The effective cases were divided into the common group and the severe group according to clinical manifestations，25 cases in each group. At the same time，20 cases of non HFMD without neurological infections were collected as a negative control group. Serum levels of S-100β protein in acute and recovery stage of severe HFMD group and common HFMD group were detected by the ELISA kit of human S-100β protein. Acute phase serum S-100βprotein was detected in the negative control group. The cranial magnetic resonance was used by the severe HFMD group and common HFMD group. Result：The S-100β protein in acute stage of severe HFMD group was higher than that of the negative control group，the difference was statistically significant（P<0.001）.The S-100β protein both in acute and recovery stage of severe HFMD group were higher than those of common HFMD group， the differences were statistically significant（P<0.001）.The occurrence of abnormal cranial magnetic resonance in severe HFMD group was 72.0%，which was higher than 16.0% of common HFMD group，the difference was statistically significant（ χ2=15.909，P<0.001）.The occurrence of sequela in severe HFMD group was 24.0%，which was higher than that of common HFMD group，the difference was statistically significant（ χ2=4.735，P=0.030）.The acute and recovery phase of S-100βprotein in cranial magnetic resonance abnormalities group were significantly higher than those of cranial magnetic resonance normalities group， the differences were statistically significant（P<0.001）.The occurrence of sequelae in abnormal cranial magnetic resonance examination group was 27.3%，which was higher than that of normal cranial magnetic resonance group， the difference was statistically significant（P=0.012）. Conclusion：The levels of S-100β protein can be used to early judge whether the HFMD combined with central nervous system infection and early identification whether the HFMD developed to severe cases.The serum levels of S-100β protein combined with cranial magnetic resonance test can evaluate the degree of brain damage and the prognosis of HFMD.
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