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Abstract Objective：To investigate the correlations between ultrasonographic features and molecular biological indexes such as ER（estrogen receptor），，PR（progesterone receptor），C-erbB-2（ human epidermal growth factor receptor 2）and Ki-67 in invasive duct carcinoma of breast（IDC）.Method：The data of 107 IDC patients who were in our hospital from January 2012 to June 2014 were collected.Their ultrasonographic data and immunohistochemical pathologic results were analyzed.Result：The positive expression rates of ER，PR in patients with spiculation were higher than those in patients without spiculation，the positive expression rates of ER，C-erbB-2 and Ki-67 in patients with microcalcification were higher than those in patients without microcalcification，the positive expression rate of C-erbB-2 in patients with suspicious lymph node was higher than that in patients without suspicious lymph node，the positive expression rate of C-erbB-2 in patients with rich blood flow signals was higher than that in patients with poor blood flow signals，the differences above were all statistically significant（P<0.05）. Conclusion：There is a certain correlation between ultrasonographic features and molecular biology markers in invasive duct carcinoma of breast. The expression results of ER，PR，C-erbB-2 and Ki-67 of IDC can be predicted according to the ultrasonographic features，which can provide a basis for the biologic behavior assessment，prognosis and clinical treatment.
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