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| Efficacy Evaluation of Rabeprazole-based Sequential Therapy in Helicobacter Pylori Eradication |
| Dongtai Sancang People’s Hospital，Dongtai 224231，China |
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Abstract Objective：To compare the efficacy and safety of Rabeprazole-based 10-days sequential therapy including Rabeprazole，Amoxicillin，Clarithromycin，Furazolidone，with 10-days standard triple therapy including Omeprazole，Amoxicillin，Furazolidone in Helicobacter pylori.eradication.Method：A total of 160 Helicobacter pylori patients with infection in active peptic ulcer were recruited and randomly assigned into the treatment group and the control group，80 cases in each group.The treatment group（sequential therapy） was implemented with RA program which included orally taking Rabeprazole 10 mg per time，Amoxicillin 1000 mg per time，twice per day in the first five days，after the five days，the treatment group was implemented with RCF program which included orally taking Rabeprazole 10 mg per time，Clarithromycin 500 mg per time，Furazolidone 100 mg per time，twice per day for five days，then the treatment group was given Rabeprazole 10 mg once per day for three weeks.The control group（standard triple therapy） was implemented with OAF program which included orally taking Omeprazole 20 mg twice per day，Amoxicillin 1000 mg twice per day，Furazolidone 100 mg twice per day for 10 days，then the control group was given Omeprazole 20 mg，once per day for three weeks.Four weeks after the completion of treatment，the efficacy and safety were evaluated by gastroscopy，rapid urease test and 14C urea breath test were determined for Helicobacter pylori.Result：A total of 156 patients completed the treatment.With intention-to-treat（ITT） analysis，the Helicobacter pylori eradication rate in the treatment group was 92.50%（74/80），which was significantly higher than 78.75%（63/80） of the control group，the difference was statistically significant（ χ2=19.262，P<0.01）.With per protocol（PP） analysis，the Helicobacter pylori eradication rate in the treatment group was 94.87%（74/78），which was significantly higher than 80.77%（63/78） of the control group，the difference was statistically significant（ χ2=15.566，P<0.01）.The incidence of adverse reaction rates of the treatment group and the control group were 18.75%（ 15/80） and 22.50%（18/80） respectively，there was no statistically significant difference（P>0.05）.Conclusion：The 10-days sequential therapy including Rabeprazole，Amoxicillin，Clarithromycin，Furazolidone is more effective than 10-days standard triple therapy including Omeprazole，Amoxicillin，Furazolidone in eradicating Helicobacter pylori，can achieve a very high rate of Helicobacter pylori eradication and good curative effect.The individual difference is small，the incidence of adverse reaction is low，the patients’ compliance is good，it is worthy to be popularized in clinic.
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