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| Clinical Comparison of Different Cervical Conization Schemes in the Treatment of High-grade Cervical Intraepithelial Neoplasia |
| FU Huiqin |
| Zhangshu Third People's Hospital, Jiangxi Province, Zhangshu 331200, China |
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Abstract Objective: To compare and analyze the application effect of loop electrosurgical excisional procedure (LEEP) and common electrosurgical knife conization (EKC) in patients with high-grade cervical intraepithelial neoplasia (CIN). Method: A prospective randomized controlled study was used in this study, 84 cases of high-grade CIN patients admitted to the Zhangshu Third People's Hospital from January 2018 to June 2021 were selected, they were divided into LEEP group (received LEEP treatment) and EKC group (received EKC treatment) by random number table method, with 42 cases in each group. The general data, operation time, intraoperative blood loss, conization height, conization area and the status of incision margin were compared between the two groups; human papillomavirus (HPV) infection, lesion residual, recurrence and complications were compared between the two groups. Result: There were no significant differences in operation time and intraoperative blood loss between the two groups (P>0.05). The cone-cutting area in LEEP group was lower than that in EKC group, and the cone-cutting height in LEEP group was lower than that in EKC group, the differences were statistically significant (P<0.05). The positive rate of incisal margin in LEEP group was higher than that in EKC group, the difference was statistically significant (P<0.05). Before operation, there was no significant difference in HPV infection rate between the two groups (P>0.05). After 6 months of operation, the infection rate of HPV in both groups were lower than those before operation, the differences were statistically significant (P<0.05). However, there was no significant difference in HPV infection rate between the two groups after 6 months of operation (P>0.05). There was no significant difference in lesion residual rate between the two groups (P>0.05). The recurrence rate in LEEP group was higher than that in EKC group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: The operation time and intraoperative bleeding volume of LEEP and EKC in the treatment of high-grade CIN are similar, but EKC has more advantages in maintaining the cutting depth, removing the focus and reducing the positive rate of the cutting edge, and LEEP and EKC have better safety in the treatment of high-grade CIN.
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Received: 27 September 2022
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