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| Effect of Remote Ischemic Preconditioning on Cognitive Ability of Patients with Subcortical Ischemic Vascular Dementia |
| LI Keying |
| First-author's address: Jiamusi Central Hospital, Heilongjiang Province, Jiamusi 154002, China |
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Abstract Objective: To evaluate the effect of remote ischemic preconditioning (RIPC) on cognitive ability in patients with subcortical ischemic vascular dementia (SIVD). Method: A total of 74 patients with SIVD diagnosed and treated in Jiamusi Central Hospital from January 2019 to January 2021 were selected and divided into the treatment group (36 cases) and the control group (38 cases) according to random number table method. The treatment group was treated with RIPC treatment and the control group was treated with placebo for 3 months. The cognitive ability scores, serum inflammatory factors and MRI parameters of the two groups were compared before and after treatment. Result: There were no significant differences in cognitive ability scores, serum inflammatory factors and imaging parameters between the two groups before treatment (P>0.05). After treatment, Hopkins verbal learning test-revised (HVLT-R), controlled oral word association test (COWAT), trail making test A and B (TMT-A, TMT-B) and judgment of line orientation (JLO) scores in the treatment group were better than those before treatment (P<0.05); all the inflammatory factors in the treatment group were lower than those before treatment and those in the control group (P<0.05), in the control group, only HVLT-R and TMT-B scores were significantly better than those before treatment (P<0.05). Before and after treatment, there were no significant differences in MRI parameters between the two groups (P>0.05). All patients successfully completed the treatment without obvious adverse reactions. Conclusion: RIPC can improve the cognitive function of SIVD patients to a certain extent without obvious adverse reactions.
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Received: 11 July 2023
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