Abstract Objective：To discuss the role of PCT levels detection in the anti-infective therapy on the elder patients with COPD and lung infections.Method：86 elder patients with COPD and lung infections were selected and divided into the PCT group（ n=52） and the empirical treatment group（ n=34）， patients on the were detected and antibiotic therapy according to the PCT levels， patients on the empirical treatment group were treated according to the clinical experience and clinical symptoms. The anti-infection treatment time， length of stay， clinical efficiency， functional status score， super-infection rate， course increase and mortality of both group were observed and compared. Result：The antiinfection treatment time， length of stay and super-infection of the PCT group were statistically shorter than the empirical treatment group（ P<0.05）. And the clinical efficiency， functional status score， course increase and mortality of the two
groups were not statistically significant（ P>0.05）.Conclusion：The levels of PCT can be used to guide the anti-infective therapy of elder patients with COPD and lung infections， conducive to reduce the use of antibiotic and shorter hospital stays， reduce super-infection rate， can avoid bacterial resistance arising from excessive use of antibiotics.
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