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| Comparison on Treatment of Neonatal Respiratory Distress Syndrome by Nasal Bi-level Positive Airway Pressure Ventilation and Continuous Positive Pressure Ventilation |
| Mudan District’s Maternal and Child Healthcare Hospital，Heze 274000，China |
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Abstract Objective： To compare the clinical effect and safety on treatment of neonatal respiratory distress syndrome（NRDS） by nasal bi-level positive airway pressure ventilation（BiPAP） and continuous positive pressure ventilation（NCPAP）， to guide NRDS’ clinical treat. Method： 78 cases with NRDS were selected from March 2012 to August 2014， and were randomly divided into observation group and control group， 59 cases in each group. Patients in control group were given NCPAP， and patients in observation group were given BiPAP based on the application of pulmonary surfactant（PS）. Arterial blood gas index on time points of before treatment（T0），1 h（ T1），12 h（T2），24 h（T3） after treatment， also with clinical effect， duration of ventilation， oxygen therapy time， hospitalization time and complications of two groups were compared. Result： PH on T3， PaO2 on T2 and T3， PaO2/FiO2 on T1， T2 and T3 of observation group were all higher than those of control group at the corresponding time points，the differences were statistically significant（t=3.10-7.39，P<0.05 or P<0.01）.PaO2 on T2，T3 were lower than control group （t=3.21，4.87，P<0.05）.Efficiency in observation group and control group were 94.87% and 86.84%， the difference was statistically significant（ 字2=2.11，P>0.05），and complication rates were 26.32% and 15.38%，the difference was statistically significant（ 字2=4.27，P<0.05）. Duration of ventilation， oxygen therapy and hospitalization time were all lower than those of control group，the differences were statistically significant（ t=3.17-6.25，P<0.05 or P<0.01）.Conclusion：BiPAP ventilation increases alveolar gas exchange， improves oxygenation capacity by variety of mechanisms， also it improves NRDS cases’ arterial blood gas index and clinical symptoms，has higher efficiency and lower complications， and gets more satisfactory clinical efficacy and it is superior than NCPAP， and it has certain guidance and reference significance to NRDS’ clinical treatment.
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