Abstract Objective：To explore the prevalence and study the clinic significance of autoimmune liver diseaserelatedantibodies in patients with primary biliary cirrhoses（PBC）.Method：The anti-AMA in 61 PBC（PBC group），50 AIH（AIH group） and 52 other liver diseases（control group） were detected by IIF.Anti-AMA-M2，anti-GP210，anti-SP100，anti-SLA，anti-LC1 and anti-LKM-1 antibodies were measured by ELISA.Result：The positive rates ofanti-AMA，anti-AMA-M2，anti-GP210，anti-SP100，anti-LC1，anti-SIA and anti-LKM-1 antibodies were 91.8%（56/61），86.9%（53/61），36.1%（22/61）， 24.6%（15/61），1.6%（1/61），0（0/61）and 1.6%（1/61）in PBCgroup；18.0%（9/50），6.0%（3/50），8.0%（4/50），14.0%（7/50），0（0/50），6.0%（3/50）and 4.0%（2/50）in AIH group；5.8%（3/52），1.9%（1/52），5.8%（3/52），11.5%（6/52），0（0/52），0（0/52）and 0（0/52）respectively in control group.Anti-AMA，anti-AMA M2 and anti-GP210 were detected more frequently in PBC groupthan AIH group（P<0.01），while anti-SLA was detected more frequently in AIH group than PBC group（P<0.01）.Conclusion：Anti-LC1， anti-SLA and anti-LKM-1 antibodies in PBC and AIH were detected at a very low frequencyin the corhort.There was little significance for screening anti-LC1，anti-SLA，anti-LKM-1 antibodies in patients withautoimmune liver diseases.It is of importance to detect anti-AMA and anti-GP210 antibodies for diagnosis of PBC.
|
|
|
|
|
|
