Abstract Objective： To evaluate the efficacy and safety of Clopidogrel Betahistine， Danshen injection inthe treatment of vertebral basilar insufficiency（ Vertebral-basilar artery insufficiency， VBI）. Method： Inclusion andexclusion criteria in strict accordance with VBI patients enrolled 120 cases， according to a list of random numbers into thetreatment group of 60 patients received Betahistine 10-30 mg， 5% dextrose injection or 0.9% sodium chloride injection，a after day 1， Danshen injection， intravenous infusion， a 10-20 mL with 5% glucose injection 100-500 mL diluted afteruse， day 1， and oral Clopidogrelbisulfate tablets， for the first time to give 600 mg， 150 mg/d. The control group receivedbetahistine joint compound Danshen injection. Two consecutive 7-21 d after treatment to assess the extent of the patient’svertigo， and using TCD to detect vertebral-basilar artery blood flow velocity and blood rheology， and follow 30 d， observedthe occurrence of recent TIA or cerebral infarction. Result： The treatment group was 0-2 h from patients and 0-6 heffective accounting effect from patients was 48.3%， 36.7%. The proportion of patients in the control group 0-2 h onsetpatients and 0-6 h onset was 28.3%， 58.3%. Treatment group was efficient， the total efficiency was 65.0% and 93.3%，respectively， in the control group significant efficiency， total efficiency of 41.7% and 75.0 %. There was significantdifference between the twogroups（ P<0.05）. After the triple therapy treatment group left vertebral artery， right vertebralartery， basilar artery blood flow velocity， blood viscosity， plasma viscosity， erythrocyte aggregation index improvedsignificantly better than the control group， a significant difference between the two groups（ P<0.05）. Long-term follow30 d， the treatment group 0 case of TIA or stroke occurred in the control group four cases occurred TIA， 1 case developedinto stroke incidence was 9.2%. There was significant difference between the two groups（ 字2=4.627， P=0.031）. Both
groups during the treatment of liver and kidney function did not change significantly after taking the drug. Treatment group1 patients had neutropenia，gastrointestinal adverse reactions occurred in 2 cases， nausea ， abdominal distension， etc.，shall not affect the continued drug use， the control group had no other adverse reactions. Conclusion： Clopidogrel andBetahistine， Danshen injection can significantly improve the vertebral-basilar artery insufficiency caused by vertigo，adverse reactions rarely occur during treatment.
