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| The Effect of Restlessness and Pain of Preoperative Parecoxib Sodium Injection on Resection of Gallbladder Patients |
| Longgang District People’s Hospital of Shenzhen，Shenzhen 518172，China |
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Abstract Objective：To observe the restlessness and pain effects caused by preoperative parecoxib sodium injection on resection of gallbladder patients Method：56 cases of cholecystolithiasis patients were treated in our hospital from May 2013 to November 2014 as research object，and were randomly divided into two groups，29 cases in the observation group and 27 cases in the control group.The observation group with preoperative parecoxib sodium， control group with intravenous injection of flurbiprofen axetil， the same of other drugs were used by the two groups.Two groups of patients’ VAS scores after 1， 2， 4， 12， 24 h， the incidence of agitation，and the incidence of adverse reaction were compared.Result：The observation group patients’ VAS scores after 1， 2， 4， 12， 24 h were significantly lower than those in control group， suggested that the pain was lighter，the difference was statistically significant（P<0.05）.The incidence
of agitation rate of patients in observation group was 6.8%（ 2/29），significantly lower than the control group of 29.6% （8/27）， the difference was statistically significant（P<0.05）.In addition， observation group of adverse reaction of nausea and vomiting，and itch of skin were also significantly lower than control group， the difference was statistically significant （P<0.05）.Conclusion：Parecoxib sodium has good effect of analgesia in laparoscopic cholecystectomy surgery， sedative effect of analepsia period is significant， but also effectively in prevent restlessness， nausea and vomiting adverse reaction，wide application prospect， is worthy of promotion.
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