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Abstract Objective：To investigate the affect of the serum B lymphocytes stimulating factor（BlyS） on the anti-IgE antibody and anti-FcεRI antibody of the patients with chronic idiopathic urticaria. Method： 100 cases of patients with chronic idiopathic urticaria were selected as disease group， 100 cases of healthy people in the same period were selected as the healthy group. The serum level of the BlyS， anti-IgE antibody and anti-FcεRI antibodies were detected；the B lymphocytes from the peripheral blood of the disease group patients were isolated and cultured， and divided into two shares， add BlyS in one share as the experimental group，another share as blank control group，the level of the anti-IgE antibody and anti-FcεRI antibodies were detected. The relationship among the BlyS，anti-IgE antibody and anti-FcεRI antibodies were analyzed. Result：The serum levels of the BlyS，anti-IgE antibody and anti-FcεRI antibodies of the disease group were significantly higher than the healthy group，the differences had statistical significance（ P<0.05）.The levels of the BlyS，anti-IgE antibody and anti-FcεRI antibody of the experimental group were significantly higher than the control group， the differences had statistical significance（P<0.05）. The levels of the anti-IgE antibody and anti-FcεRI antibodies of the experimental group were positively correlated with the BlyS（ r=0.765，0.722，P<0.05）.Conclusion：BlyS can stimulate B lymphocytes to produce the anti-IgE antibody and anti-FcεRI antibodies of patients with chronic idiopathic urticaria， this may be related to the pathogenesis of chronic idiopathic urticaria.
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