Abstract Objective： To explore the rational emotive therapy effect in the prevention of occupation burnout of medical staff. Method： From July 2013 to October 2014， voluntary participation in the activities of the medical staff were randomly selected，including 500 clinical frontline nurses and 300 doctors as the research object， the reasonable mood therapy for 2 months on the existence of occupation burnout 100 nurses and 60 patients with the doctor were carried on， a questionnaire survey was conducted before and after the intervention of occupation burnout occupation burnout，score statistics before and after intervention. Result： After the intervention ， nursing staff and medical personnel occupation burnout scores were respectively（ 167.38±8.43），（162.83±11.29），compared with（ 217.83±15.29）and（ 209.43±14.27） before the intervention were significantly decreased， the differences were statistically significant
（t=14.283，11.853，P<0.05）. Nursing staff and medical personnel after the intervention，the proportion of severe scores decreased significantly， the proportion of mild and moderate scores improved significantly， the differences were statistically significant（P<0.05）.Conclusion： The rational emotive therapy can improve the ease of the medical staff occupation burnout.
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