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| Relationship and Nursing Countermeasures of Antinuclear Antibodies， Liver Specific Autoantibodies with Chronic Hepatitis B |
| Central Hospital of Longhua New District in Shenzhen City，Shenzhen 518110，China |
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Abstract Objective：To study relationship and nursing countermeasures of antinuclear antibodies， liver specific autoantibodies with chronic hepatitis B.Method：From March 2013 to March 2014 in our hospital for treatment of 100 cases of patients with chronic hepatitis B（ CHB） as the research object.Chose 92 cases in our hospital received physical examination of normal persons as control group， the related antibodies， CHB from positive and negative group of related indicators， nursing care of patients before and after treatment adherence of two groups were compared. Result：Chronic hepatitis B group’s ANA positive rate was 24.00%（ 24/100）， was significantly higher than the control group’s 4.35% （4/92）， the difference was statistically significant（ P<0.05）.CHB group since the positive resistance layer adhesion proteins（ LN） and hyaluronic acid（ HA）， and collagen type Ⅳ levels were significantly higher than the negative resistance groups， differences were statistically significant（ P<0.05）.Two groups in ALT， AST， HBV quantitative was contrast and HBV parting， there were no statistically significant difference（ P>0.05）.After nursing of treatment adherence for patients with chronic hepatitis B was significantly higher than before treatment， the difference was statistically significant（ P<0.05）. Conclusion：There are more antibody in serum of patients with chronic hepatitis b， but the ANA and the prognosis of patients with liver disease related antibody assay for predicting and outcome has great significance， it could be one of the causes of liver cirrhosis after hepatitis B.At the same time， nursing countermeasures for patients and can increase treatment adherence to care，worthy of clinical attention.
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