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Abstract Objective：To study the efficiency and safety of TCD assisted r-tPA intravenous thrombosis to treat patient with middle artery infraction.Method：62 patients with acute ischemic middle artery infraction divided into experimental and control group.Experimental group was monitored by TCD within 2 h of thrombolysis and the control group was treated with thrombolytic therapy.Comparison of two groups of vascular recanalization rate，2 weeks and 3 months of neural function defect（NIHSS，BI index），complicated with intracranial hemorrhage and death.Result：The recanalization rate of experimental group was significantly higher than the control group（60.0% vs 34.3%）.Besides，the degree of neural functional defect of experimental group was greatly improved than the control group.Combined with TCD also resulted in an increase of intracranial hemorrhage and directly related mortality，but there is no significant difference between two groups.Conclusion：The recanalization rate and recovery of neurological function of TCD combined with thrombolytic therapy are much better than intravenous thrombosis， while the mortality is equal in two groups.
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