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| The Curative Effect of Pulmonary Surfactant and Inhaled Nitric Oxide in Acute Lung Injury |
| Guangzhou No.1 People’s Hospital，Guangzhou 510180，China |
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Abstract Objective：To evaluate the curative effect of inhaled nitric oxide（iNO） and pulmonary surfactant（ Surf） in treatment of in acute lung injury. Method：50 healthy New Zealand rabbits were randomly divided into Surf treatment groups， iNO inhalation therapy group， Surf group， iNO inhaled combination therapy group， intraperitoneal injection of sterile saline group，simple mechanical ventilation group and the normal group. In addition to the normal group， the other E. coli strains were taken standard intraperitoneal injection，induced ALI. of respiratory mechanics，blood gas and other conditions change were monitored.Result：Normal control group， Surf group， iNO group， when combined group on the basis of status， respiratory system dynamic compliance（Cdyn），PaO2/FiO2 was no significant difference（P>0.05）.ALI lung injury in each group，Cdyn and PaO2/FiO2 was no significant difference（P>0.05），but compared to the normal group，Cydn，PaO2/FiO2 significantly lower statistically significant（P<0.01）.Surf group after treatment，compared with oxygenation iNO group，the control group showed a significant improvement in performance（P<0.05），but the combined group the most significant role in improving oxygenation.Conclusion：Septic ALI，take NO inhalation，can immediately improve oxygenation，but can not reduce the pathological damage the lungs，short duration.Surf taken after application， pulmonary function，improves oxygenation of the lungs Surf compensation Sur function enables improved lung pathology damage mitigation.Taken in combination with inhaled NO and Surf，can alleviate the progression of infectious ALI，better than alone，is worthy of further study.
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