Abstract Objective：To study the efficiency of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning.Method：87 cases of delayed encephalopathy caused by carbon monoxide poisoning admitted to our department， were randomly divided into two groups：the control group（ n=42） was given conventional hyperbaric oxygen，preventing platelet aggregation，improving microcirculation，improving cerebral metabolism and other conventional treatment；the experimental group（ n=45） was given Ganglioside（ 100 mg， intravenous drip 1/d）， Edaravone（ 30 mg，intravenous drip 2 /d） for 21 days on the basis of the control group. The efficiency of two groups were observed and their cognitive function and daily life activity with the mini-mental state examination（ MMSE） and modified Barthel index（ MBI） before treatment and after treatment were evaluated.Result：The efficiency of the control group was 76.2%， the efficiency of the experimental group was 93.3%（P<0.05）. MMSE score and MBI score of the control group and experimental group after treatment were higher than those of before treatment（P<0.05）；MMSE score and MBI score of the experimental group were obviously higher than those of the control group after treatment（P<0.05）. Conclusion：Application of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning can obviously improve the prognosis of delayed encephalopathy， and significantly improve the patients’ cognitive ability and daily life ability.
