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Abstract Objective： To investigated the level of application value of combined detection HE4 and CA125 in serum for the diagnosis of ovarian epithelial tumors. Method： 165 patients with ovarian tumor were selected，87 cases were ovarian epithelial cancers group，78 cases were benign ovarian tumors group and 50 cases were healthy women as control group，and all of them were detected by the methods of ELISA of CA125 in serum and HE4 in blood.Result： The level of HE4 in blood with epithelial ovarian cancer patients were significantly higher than that in benign ovarian tumor group and the control group，the difference was statistically significant（P<0.05）. The sensitivity and accuracy of HE4 in blood were 87.3% and 92.3% respectively，the sensitivity and accuracy reached up to 96.5% and 97.4% by combined detection of HE4 in blood and CA125 in serum，the difference was statistically significant（P<0.05）. Conclusion： The diagnostic rate of ovarian epithelial cancer can be improved significantly by combined detection of HE4 in blood and CA125 in serum.
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