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Abstract Pulmonary hypertension associated with left heart disease (PH-LHD) is the most common form of pulmonary hypertension (PH) and a common complication in the late stage of left ventricular disease, and PH patients have poor prognosis and high mortality. At present, the formation mechanism of PH-LHD pulmonary vascular remodeling is not completely clear in China and abroad. It may be due to multi-factor effects, which is related to vasoactive substances, activation of the sympathetic nervous system, renin-angiotensin-aldosterone system, inflammatory factors, left atrial dysfunction, etc. This article will review the definition, hemodynamics and pathophysiological mechanism of pulmonary vascular remodeling of PH-LHD.
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Received: 11 November 2022
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