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| Effect of Intravenous Thrombolysis Bridging to Mechanical Thrombectomy in Acute Cerebral Infarction and Its Influence on Neurological Function |
| JIANG Aimin |
| First-author's address: Chibi General Hospital, Hubei Province, Chibi 437300, China |
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Abstract Objective: To investigate the effect of intravenous thrombolysis bridging to mechanical thrombectomy in acute cerebral infarction and its influence on neurological function. Method: A total of eighty patients with acute cerebral infarction diagnosed and treated in Chibi General Hospital from January 2020 to January 2022 were selected and divided into the observation group and the control group with 40 patients in each group using the random number table method. The control group was treated with intravenous thrombolysis alone, while the observation group was treated with intravenous thrombolysis bridging mechanical thrombectomy, and the total effective rate of treatment, revascularisation rate, prognosis, neurological function [national institutes of health stroke scale (NIHSS) score] and inflammatory response indexes [C reactive protein (CRP), interleukin-6 (IL-6) and neuron-specific enolase (NSE)] of the two groups were compared. Result: The total effective rate of treatment (92.50%) in the observation group was higher than that in the control group (75.00%) (P<0.05). The revascularisation rate and ≤30% stenosis rate in the observation group were higher than those in the control group (P<0.05). The intracranial haemorrhage rate and mortality rate within 3 months after surgery were not significantly different between the two groups (P>0.05). Before treatment, there was no significant difference in the NIHSS scores between the two groups (P>0.05); immediately after treatment, 24 h, 3 d and 2 weeks, the NIHSS scores decreased in both groups, and the scores in the observation group were lower than those in the control group (P<0.05). Before treatment, the levels of CRP, IL-6 and NSE were not significantly different between the two groups (P>0.05); 3 days after treatment, CRP, IL-6, NSE decreased in both groups, and the observation group were lower than those of the control group (P<0.05). Conclusion: Intravenous thrombolysis bridging with mechanical thrombectomy is effective in treating acute cerebral infarction, with good prognosis, contributing to the recovery of neurological function and reducing the inflammatory response.
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Received: 06 April 2023
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