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| Application of Dexmedetomidine Combined with Ropivacaine in Analgesia during Labor and Its Effect on Prolactin, NO and IL-6 |
| LIU Ying, CHEN Yongqiang, CHEN Zhenhua, LIU Bin |
| First-author's address: Fuqing Maternal and Child Health Care Hospital, Fujian Province, Fuqing 350300, China |
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Abstract Objective: To study application of Dexmedetomidine combined with Ropivacaine in analgesia during labor and its effect on prolactin, nitric oxide (NO) and interleukin-6 (IL-6). Method: A total of 105 pregnant women who gave birth in Fuqing Maternal and Child Health Care Hospital from January 2020 to January 2022 were selected for this study, and randomly divided into experimental group (n=53) and control group (n=52) by using random number table method. The control group received Ropivacaine in analgesia, the experimental group received Dexmedetomidine combined with Ropivacaine in analgesia. The analgesic effect, prolactin, NO, IL-6, labor time, pain and sedation scores, and the occurrence of adverse reactions were compared between the two groups. Result: The excellent and good rate of the experimental group was 98.11%, higher than 88.46% of the control group, the difference was statistically significant (P<0.05). There were no significant differences in prolactin, NO and IL-6 levels between the two groups at the time of labor (P>0.05); when the uterine orifice was fully opened, the levels of prolactin, NO and IL-6 were increased in both groups, and the levels of prolactin and NO in experimental group were higher than those in control group, while the levels of IL-6 were lower than those in control group, the differences were statistically significant (P<0.05). The first stage of labor in experimental group was significantly shorter than that in control group, the difference was statistically significant (P<0.05). Before analgesia, there were no significant differences in Ramsay sedation scores and VAS scores between the two groups (P>0.05); at 10 and 30 min of analgesia, VAS scores of experimental group were significantly lower than those of control group, and Ramsay sedation scores were significantly higher than those of control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dexmedetomidine combined with Ropivacaine has a significant analgesic effect in labor analgesia, which may be related to the effective improvement of prolactin, NO and IL-6 levels.
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Received: 28 April 2023
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