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| Clinical Double-blind Controlled Study of Amiodarone Combined with Metoprolol in the Treatment of Patients with Chronic Heart Failure and Ventricular Arrhythmia |
| FENG Gu |
| First-author's address: Fuzhou Hospital of Traditional Chinese Medicine, Jiangxi Province, Fuzhou 344000, China |
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Abstract Objective: To study the clinical effect of Amiodarone combined with Metoprolol in the treatment of patients with chronic heart failure and ventricular arrhythmia, and to provide clinical guidance for the recovery of patients. Method: A total of 80 patients with chronic heart failure and ventricular arrhythmia who were admitted to Fuzhou Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the research subjects. The patients were divided into a study group and a control group according to the random number table method, with 40 cases in each group. The control group was treated with Amiodarone, and the study group was treated with Amiodarone combined with Metoprolol. Before and after treatment for 3 months, the left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and left ventricular ejection fraction (LVEF) were compared between the two groups. After treatment for 1 month, 2 and 3 months, the sinus rhythm maintenance rate of the two groups were recorded. After treatment for 3 months, the total effective rate and adverse reactions of the two groups were recorded. Result: The total effective rate of the study group was 92.5%, which was significantly higher than 72.5% of the control group, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in LVEDV, LVSV and LVEF between the two groups (P<0.05). After 3 months of treatment, LVEDV and LVSV in the two groups were significantly decreased, and those in the study group respectively was (131.3±30.6), (67.3±18.4) mL, which were significantly lower than those in the control group (149.5±32.5), (85.4±19.8) mL, LVEF in the study group was significantly increased, and that in the study group group was (48.7±6.4)%, which was significantly higher than (42.9±5.7)% that of the control group, the differences were statistically significant (P<0.05). After 1, 2 and 3 months of treatment, the sinus rhythm maintenance rate in the study group respectively was 77.5%, 87.5% and 90.0%, which were significantly higher than 47.5%, 60.0% and 62.5% in the control group, the differences were statistically significant (P<0.05). The incidence of adverse reactions in the two groups respectively was 5.0% and 10.0%, the difference was not statistically significant (P>0.05). Conclusion: Amiodarone combined with Metoprolol in the treatment of chronic heart failure with ventricular arrhythmia has a significant effect, it can effectively improve the cardiac function of patients, maintain the sinus rhythm of patients, and has high safety.
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Received: 25 October 2022
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