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| Effect of Special Dietary Conditioning on Blood Glucose Variability and Oxidative Damage in Patients with Gestational Diabetes Mellitus |
| WANG Yanxiang, QU Chunyao |
| First-author's address: Maternal and Child Health Center of Jiamusi City, Heilongjiang Province, Jiamusi 154002, China |
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Abstract Objective: To investigate and analyze the effect of special dietary conditioning on blood glucose variability and oxidative damage in patients with gestational diabetes mellitus. Method: A total of 100 patients with gestational diabetes mellitus diagnosed and treated in Maternal and Child Health Center of Jiamusi City from August 2021 to August 2022 were divided into control group and observation group according to random number table method, with 50 cases in each group. The control group received routine pregnancy and diabetes intervention, and the observation group received special dietary conditioning on the basis of the control group. The blood glucose control effect, before and after intervention of oxidative damage indexes [reactive oxygen species (ROS), advanced oxidation protein products (AOPP), nitric oxide (NO)], routine blood glucose indexes [fasting plasma glucose ( FPG), 2 hours postprandial blood glucose (2 h PG), glycosylated hemoglobin (HbA1c)] and blood glucose variability related indexes [postprandial glucose excursions (PPGE), standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursion (MAGE), coefficient of variation-fasting plasma glucose (CV-FPG)] between the two groups were compared. Result: The blood glucose control effect of the observation group was significantly better than that of the control group, the difference was statistically significant (P<0.05). Before intervention, there were no significant differences in oxidative damage indexes, routine blood glucose indexes and blood glucose variability related indexes between the two groups (P>0.05). After 4 and 8 weeks of intervention, ROS, AOPP, routine blood glucose indexes and blood glucose variability related indexes were significantly decreased in both groups, and those in the observation group were significantly lower than those in the control group, NO was significantly increased, and that in the observation group was significantly higher than that in the control group, the differences were statistically significant (P<0.05). Conclusion: The special dietary conditioning can effectively control the blood glucose of patients with gestational diabetes mellitus, and also has a better effect on blood glucose variability and oxidative damage.
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Received: 23 April 2023
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