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| Effect of Blood Letting Therapy Combined with Hydroxycarbamide and Aspirin on Patients with Polycythemia Vera |
| NI Wenjuan, YUN Yan |
| First-author's address: The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China |
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Abstract Objective: To explore the effect of blood letting therapy combined with Hydroxycarbamide and Aspirin in the treatment of polycythemia vera. Method: A total of 60 patients with polycythemia vera admitted to the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology from January 2021 to January 2022 were selected and randomly divided into observation group and control group according to coin toss method, with 30 cases in each group. Patients in the the control group were treated with Hydroxycarbamide combined with blood letting therapy, and patients in the the observation group were treated with low-dose Aspirin based on the control group. The clinical efficacy, coagulation function, hematological indexes, adverse reactions, myeloproliferative neoplasm symptom assessment form total symptom score (MPN-SAF-TSS) and incidence of thrombus were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the incidence of thrombus was lower than that of the control group (P<0.05). Before treatment, there were no significant differences in coagulation function indexes between the two groups (P>0.05); after treatment, the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) in both groups were longer than those before treatment, and the APTT, PT and TT in the observation group were longer than those in the control group, and the fibrinogen (FIB) levels of both groups were decreased, and the FIB level of observation group was significantly lower than that of control group (P<0.05). Before treatment, there were no significant differences in red blood cell (RBC), hemoglobin (Hb), platelet (PLT) and white blood cell (WBC) levels between the two groups (P>0.05); after treatment, RBC, Hb, PLT and WBC levels in both groups were decreased, and RBC, Hb, PLT and WBC levels in observation group were significantly lower than those in control group (P<0.05). After treatment, MPN-SAF-TSS score of observation group was lower than that of control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Blood letting therapy combined with Hydroxycarbamide and Aspirin in the treatment of polycythemia vera can not only improve the coagulation function and hematological indexes of patients, but also improve the therapeutic effect, reduce the incidence of thrombus in patients, and do not increase adverse reactions.
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Received: 08 December 2022
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