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| Application of Low-dose Aspirin in High-risk Patients of Pre-eclampsia Risk Prediction and Its Effect on Improving Maternal and Infant Outcomes |
| HUO Nana, WANG Yonghui |
| First-author's address: Maternity and Child Health Care of Zaozhuang, Shandong Province, Zaozhuang 277100, China |
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Abstract Objective: To investigate the effect of low-dose Aspirin therapy on improving maternal and infant outcomes in patients with high-risk of pre-eclampsia (PE). Method: A total of 86 patients with high-risk of PE risk predicted in Maternity and Child Health Care of Zaozhuang from June 2019 to May 2020 were selected and divided into study group (n=43) and control group (n=43) according to random number table method. The control group was treated with routine therapy, and the study group was treated with low-dose Aspirin on the basis of the control group. The incidence of PE, coagulation function, maternal and infant outcomes and quality of life were compared between the two groups. Result: There was no significant difference in the occurrence time of PE between the two groups (P>0.05). The incidence of PE in the study group (9.30%) was lower than that in the control group (30.23%) (P<0.05). After treatment, prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) in two groups were longer than those before treatment, fibrinogen (FIB) were lower than those before treatment (P<0.05). PT, TT and APTT in the study group were longer than those in the control group, and FIB was lower than that in the control group (P<0.05). The incidence of adverse maternal and infant outcomes in the study group (6.98%) was lower than that in the control group (25.58%) (P<0.05). After treatment, the scores of generic quality of life inventory (GQOLI-74) in both groups were higher than those before treatment, and the scores of GQOLI-74 in the study group were higher than those in the control group (P<0.05). Conclusion: The application of low-dose Aspirin in the treatment of high-risk patients of PE risk prediction can reduce the incidence of PE, improve the body's coagulation function, reduce the incidence of adverse maternal and infant outcomes, and improve the quality of life.
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Received: 04 January 2023
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