Abstract Colorectal cancer has a high incidence of perioperative hypoproteinemia, which easily leads to decreased plasma colloid osmotic pressure, decreased tissue perfusion, infection, increased incidence of postoperative anastomotic leakage, and even causes serious complications such as acute kidney injury. There are many reasons of hypoproteinemia after colorectal cancer surgery. For the treatment of hypoproteinemia, careful albumin supplementation, nutritional risk screening and nutritional assessment, preoperative nutritional support for high-risk patients and early postoperative enteral nutrition program can effectively improve the postoperative albumin level, reduce the occurrence of complications and significantly improve the prognosis of patients. In addition, reasonable drugs, anesthesia and surgical selection can reduce the release of inflammatory factors, reduce stress response, reduce capillary permeability, and then reduce albumin leakage, which is an effective measure to prevent and treat hypoproteinemia after colorectal cancer surgery.
