|
|
|
| Relationship between miR-767-3p Expression Level and Epithelial-mesenchymal Transformation in Colorectal Cancer Tissues |
| CHEN Minyang |
| Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Nanchang 330003, China |
|
|
|
|
Abstract Objective: To analyze the relationship between the expression level of miR-767-3p and epithelial-mesenchymal transition in colorectal cancer. Method: Seventy patients with colorectal cancer admitted to Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to December 2021 were included in the study. miR-767-3p expression and EMT indexes in colorectal cancer tissues and normal adjacent tissues were detected: the positive rate of E-cadherin, N-cadherin, β-catenin, Vimentin, and the depth of tumor invasion and lymph node metastasis, distant metastasis were examined. The correlation between miR-767-3p and other indicators was analyzed. Result: The expression level of miR-767-3p in colorectal cancer tissues was significantly higher than that in adjacent normal tissues (P<0.05). The expression levels of miR-767-3p in cancer patients with different EMT protein expressions were significantly different, and the expression levels of miR-767-3p were significantly lower in E-cadherin (+) patients, and in N-cadherin (+) patients, β-catenin (+) patients, and Vimentin (+) patients, the expression levels of miR-767-3p were significantly higher (P<0.05). The expression of EMT proteins was significantly different between the high expression group and the low expression group of miR-767-3p. The positive rate of E-cadherin in the high expression group was lower, while the positive rate of N-cadherin, β-catenin and Vimentin were higher (P<0.05). The expression level of miR-767-3p were correlated with the expression of E-cadherin, N-catenin, Vimentin, tumor differentiation and TNM stage (P<0.05), and the correlation degree was strong (E2>0.16). Conclusion: The expression level of miR-767-3p in colorectal cancer tissues is correlated with epithelial-mesenchymal transformation of tumor cells to some extent, and it is speculated that the increased expression level of miR-767-3p in cancer tissues may lead to invasion and metastasis of cancer tissues by promoting the occurrence of EMT.
|
|
Received: 27 September 2022
|
|
|
|
|
|
|
