|
|
|
| Effects of Long Protocol in Early Follicular Phase, Antagonist Protocol and Short-acting Long Protocol in Luteal Phase on Endometrial Receptivity and Clinical Pregnancy in Patients with Infertility |
| XIA Tingting, ZENG Kefei |
| Affiliated Hospital of Jinggangshan University, Ji'an 343000, China |
|
|
|
|
Abstract Objective: To investigate the effects of long protocol in early follicular phase, antagonist protocol and short-acting long protocol in luteal phase on endometrial receptivity and clinical pregnancy in infertile patients. Method: A total of 210 female patients with infertility who received in vitro fertilization-embryo transfer (IVF-ET)/intracytoplasmic sperm injection (ICSI) for the first time in reproductive center of Affiliated Hospital of Jinggangshan University were enrolled from May 2021 to May 2022. By means of randomized control method, the patients were divided into study group 1 (n=70, long protocol in early follicular phase), study group 2 (n=70, antagonist protocol) and control group (n=70, short-acting long protocol in luteal phase). The endometrial receptivity, ovarian stimulation, embryo status and clinical pregnancy rate were compared among the three groups. Result: Before intervention, endometrial thickness (ED), endometrial volume (EV), endometrial vascular index (VI) and vascular flow index (VFI) showed no differences among the three groups (P>0.05), and the ED, EV, VI and VFI in study group 1 after intervention were higher than those in study group 2 and control group (P<0.05), and which in study group 2 were higher than those in control group (P<0.05). After intervention, the dosage and the number of use days of Recombinant Human Follitropin Alfa Solution for Injection [Gonal-F (Gn)] in study group 1 were more than those in study group 2 and control group (P<0.05), but there were no differences between study group 2 and control group (P>0.05). The level of luteinizing hormone (LH) of study group 2 was higher than those of study group 1 and control group (P<0.05), but there was no difference in LH level between study group 1 and control group (P>0.05). No differences were shown in terms of serum estradiol (E2), progesterone (P) and cycle cancellation rate (P>0.05). The effective embryo rate and high-quality embryo rate after intervention in study group 1 were higher than those in study group 2 and control group (P<0.05), but the two indicators in study group 2 and control group were no significant differences (P>0.05), and the number of transferred embryos, the number of freshly transferred cycles, whole embryo freezing and normal fertilization rate in three groups had no differences (P>0.05). The clinical pregnancy rate of study group 1 was higher than those of study group 2 and control group (P<0.05), and the clinical pregnancy rate of study group 2 and control group was no significant difference (P>0.05), and there were no differences in the number of transferred pregnancy cycles, multiple pregnancy rate, abortion rate and ectopic pregnancy rate among the three groups (P>0.05). Conclusion: Long protocol in early follicular phase can help improve endometrial receptivity, oocyte quality and clinical pregnancy in female patients with infertility, but because its down-regulation time is long, as a result, the use time of Gn is prolonged and the dosage is increased.
|
|
Received: 08 October 2022
|
|
|
|
|
|
|
