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| Effects of Neuroendoscopic Translateral Fissure Approach Hematoma Evacuation on Inflammatory Factors, Prognosis, Serum MMP-9 and GM-CSF in Patients with Hypertensive Intracerebral Hemorrhage |
| WEI Xiaobing, WEN Yiqi, LI Sumei, HU Yongzhen, LIU Yang, LONG Qingshan, HUANG Chutao, LIU Xidi |
| The Third People's Hospital of Huizhou, Guangdong Province, Huizhou 516000, China |
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Abstract Objective: To explore the effect of translateral fissure approach hematoma eva, uation on inflammatory factors, prognosis and serum granulocyte-macrophage colony-stimulating factor (GM-CSF), matrix metalloproteinase-9 (MMP-9) levels. Method: A total of 97 patients with hypertensive intracerebral hemorrhage from the Third People's Hospital of Huizhou who were treated from February 2017 to February 2022 were prospectively selected. They were divided into two groups according to the surgical method using a non randomized control method, 48 patients were treated with small bone window craniotomy hematoma clearance as the control group, and 49 patients were treated with translateral fissure approach hematoma clearance as the observation group, the results of operation were compared between the two groups. Result: The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C reactive protein (CRP), MMP-9, GM-CSF and overall improvement of prognosis in the observation group were better than those in the control group 7 days after surgery (P<0.05), the time of operation, the time of getting out of bed and the time of hospitalization were shorter than those of control group (P<0.05), the hematoma clearance rate and the score of ADL were higher than those of control group (P<0.05), and the amount of intraoperative blood loss and postoperative hematoma volume were lower than those of control group (P<0.05), the postoperative complication rate and NIHSS score were lower than those of control group (P<0.05). Conclusion: Neuroendoscopic transsylvian approach for hematoma evacuation in patients with hypertensive intracerebral hemorrhage can improve the hematoma clearance rate and prognosis.
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Received: 10 October 2022
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