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| Research on Application of Individual Chemotherapy in the Treatment of Drug Resistant Tuberculosis Patients |
| Disease Prevention and Control Center of Qihe County，Qihe 251100，China |
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Abstract Objective：To compare the effect of the three different treatment plans for multi-drug resistant tuberculosis and explore the superiority of individualized treatment so as to provide the reference for the clinical treatment of drug-resistant tuberculosis.Method：150 patients with drug-resistant tuberculosis in our center from January 2009 to January 2013 were selected.Among them，50 patients were given standard treatment [6Z Km（ Am，Cm） Lfx（ MFX） Cs（ PAS，E） Pto/ 18Z Lfx （Mfx） Cs（ PAS，E） Pto]，50 patients were given individualized treatment [6ZEMfxCs（ Am） Pot/ 18ZEMfxPtoPas] and the other 50 cases were given experienced treatment（one second-line injection was chosen from kanamycin and Amikacin，if the resistance happened，then selected capreomycin.The Injection had to be used for at least 6 months.2-3 oral second-line drugs were chosen，the select order was amino acid，cycloserine and protionamide.The treatment continued for at least 18 months after the cultures turned negative）.The therapeutic effect of three therapeutic schemes for patients with drug-resistant tuberculosis were analysed.Result：The sputum negative conversion rate（ 70.00%） and X-ray improvement rate（70.00%） of the individualized treatment group were significantly higher than that of the standard treatment group（58.00%，50.00%） and the experienced treatment group（34.00%，42.00%），the differences were statistically significant（P<0.05）. Conclusion：For the treatment of drug resistant tuberculosis，the individualized treatment plan is better than the standard and experienced treatment plan.
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