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Abstract Objective：To discuss and investigate the implementation of investigation of mixed infection of atypical pathogenic bacteria in patients with COPD ，and the significance of actively implement the treatment and efficacy evaluation.Method：200 patients with COPD in our hospital from July 2012 to April 2014 were selected，they were randomly divided into the control group and the treatment group，100 cases in each group.The control group was given conventional treatment.On the basis of conventional treatment，the treatment group was given routine examination of atypical pathogens mixed infection and the etiological examination results were analyzed in detail.Result：Before anti infection scheme adjustment，the treatment effect of treatment group was significantly better than the control group（P<0.05）.After anti infection scheme adjustment，there were no statistically significant differences in the treatment effect and mortality between the two groups（P>0.05），and the treatment effect of control group was significantly better thanbefore the adjustment（P<0.05）.Conclusion：Carrying out the investigation of mixed infection of atypical pathogenic bacteria in patients with COPD，can improve the treatment effect of the patients.
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