Abstract Objective：To explore effects of anticoagulant therapy on the pregnancy outcome in pregnant women with pregnancy thrombophilia.Method：60 patients with pregnancy thrombophilia from February 2012 to March 2015 in our hospital were divided randomly into experiment group and control group， with 30 patients in each group.The experiment group was given anticoagulant therapy but the control group was not given.And then，preliminary study on relationship between coagulation function changes and thrombophilia occurred and the situation on pregnancy outcomes of pregnant women were researched and analyzed.Result：D-dimer levels of experiment group was significantly lower than the control group（P<0.05）.There were no significant differences between the two groups on prothrombin time，fibrinogen，platelet count and prothrombin time（ P>0.05）； Preterm children，great children，asphyxia，fetal distress of the experiment group were significantly fewer than those of the control group according to the statistical analysis（P<0.05）； there were no significant differences on huge children or fetal death（P>0.05）.Conclusion：Anticoagulant therapy has a very important value in the improvement of the pregnancy outcome of patients with pregnancy thrombophilia.
