|
|
|
| The Relationship of Heart-type Fatty Acid-binding Protein Levels and Chronic Heart Failure |
| Central Hospital of Jilin，Jilin 132011，China |
|
|
|
|
Abstract Objective：To investigate the relationship of heart-type fatty acid- binding ng protein（ H-FABP） and chronic congestive heart failure（ CHF）.Method：The CHF group included 80 patients with CHF，they were divided into NYHA Ⅱ， Ⅲ and Ⅳ three subgroups. The control group were 65 healthy person.Serum concentrations of H-FABP，NT-proBNP and cTnI of two groups were measured. Followed-up at least a year， the major adverse cardiac events were recorded. Result：Serum concentrations of H-FABP，NT-proBNP and cTnI of CHF group were higher than control group，the differences were statistically significant（P<0.05）.The level of H-FABP，NT-pro BNP increased gradually of CHF subgroups with the different classification， the differences were statistically significant（P<0.05），but there was no significant difference between cTnI subgroup and CKMB subgroup（P>0.05）. The deaths proportion of H-FABP positive group and NT-proBNP positive group were higher than the rest two groups，but had no statistical difference（P>0.05）.The incidence of readmission and refractory heart failure in H-FABP positive group were higher than cTnI group and CKMB group，the differences were statistically significant（ P<0.05）. Multiariable logistic regression analysis found that NT-proBNP and H-FABP associated with all-cause mortality（P<0.05）.Conclusion：The detection of H-FABP can be help for assessment risk stratification and prognosis for patients with CHF.
|
|
|
|
|
|
|
|
|
