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| The Effect Observation of Paroxetine Combined with Olanzapine in Treatment of Obsessive-compulsive Disorder |
| The Third People’s Hospital of Ji’an City，Ji’an 343000，China |
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Abstract Objective：To evaluate the clinical efficiency of Paroxetine combined with Olanzapine in treating obsessive-compulsive disorder. Method：80 patients with obsessive-compulsive disorder were randomly divided into study group and control group，40 cases in each group. Paroxetine and Olanzapine were given to the study group，while only paroxetine was given to the control group，the treatment course were 8 weeks.Yale-Brown obsessive compulsive scale（ Y-BOCS），Hamilton anxiety scale（HAMA） were used before treatment and after 8 weeks treatment to assess the efficacy，treatment emergent symptom scale（ TESS） was used to assess the side effects. Result：The total effective rate of observation group was higher than that of control group，the difference was significant（ P<0.05），while after 8 weeks treatment，Y-BOCS，HAMA scores between the two groups had significant difference（P<0.05）.While after 1，2，4，8 weeks treatment，TESS scores between the two groups had no significant difference（P>0.05）.Conclusion：Paroxetine combined with Olanzapine in treatment of obsessive-compulsive disorder can improve therapeutic efficacy，the security is better，not increase adverse reactions.
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