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Abstract Objective：To evaluate the effect and safety of large dosage iodized oil（1ipiodol） treatment in huge primary hepatic carcinoma（PHC） via injecting from hepatic artery transarterial chemoembolization（TACE）. Method：One hundred sixty-six cases of huge PHC received 20 mL lipiodol or 25-45 mL lipiodol injection in each TACE.Tumor maximal diameter and liver function were recorded both before and after TACE.Angiography，lipiodol dosage and deposition in tumor and complications were also recorded.Result：All patients were followed-up 1 and 4 weeks after TACE respectively.The average dosage of large-lipiodol was 28.3 mL.Tumor maximal diameter was decreased[（13.15±5.32）cm vs（ 11.98±3.08）cm ].There was no statistical significance before and after operation in the two groups（P>0.05）.Some impairment of liver function was found in those patients after TACE 1 week.No major impairment of liver function was found in those patients after TACE 2 week.Median survival time of the conventional dose group were 6 months，while large dose group were 8 months.The survival rates of 6，12，18，24 months after treatment were 55.8%，32.2%，24.0%，13.7%.No severe complication happened in this series.The survival time of large dose group was longer than that of the conventional dose group， with statistical significance（P<0.05）. Conclusion：It is effective and safe for patients with huge primary liver cancer patients to receive high dose lipiodol TACE.The effect of large dose lipiodol treatment on mass hepatocellular carcinoma is superior to the common.
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