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| Expression of VEGF and SSTR and Correlation Research in Patients with Gastric Cancer |
| Almond Altar Hospital Affiliated the First People’s Hospital， Shunde District，Foshan 528325， China |
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Abstract Objective： To study the expression of VEGF and SSTR and their correlations in patients with gastric cancer. Method： 90 patients with gastric cancer treated from January 2010 to December 2014 in our hospital were selected as gastric cancer group and 60 healthy check-ups were selected as control group. Through
immunohistochemistry staining methods， the expression of VEGF and SSTR in different gastric mucosa tissues were detected. Result： The positive rate of VEFG in gastric cancer group was 62.2%（ 56 cases）； the positive rate of VEGF in the control group was 8.3%（ 5 cases）（ P<0.05）； the gastric cancer group contained 73 positive cases in SSTR1（ 81.1%）， 67 positive cases in SSTR2（ 74.4%） and 47 positive cases in SSTR3（ 52.2%）； the control group contained 47 positive cases in SSTR1（ 78.3%）， 56 positive cases in SSTR2（ 93.3%） and 51 positive cases in SSTR3（85.5%）； the positive expression of SSTR1 of the two groups was not significantly different（ P>0.05）； the positive rate of SSTR2 and SSTR3 of the gastric cancer group was lower than that of the control group（ P<0.05）. VEGF expression was significantly correlated with SSTR2 and SSTR3 expression in gastric cancer tissues（ P<0.05）； VEGF expression was not closely correlated with SSTR1 expression（ P>0.05）. Conclusion： VEGF is highly expressed while SSTR is lowly expressed in gastric cancer tissues. VEGF is negatively correlated with SSTR， which indicates that the up-regulation of VEGF during signal transduction of occurrence and development of gastric cancer will cause the loss of SSTR.
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