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| Effect and Possible Mechanism of Lanthanum Carbonate on Vascular Calcification in Dialysis Patients |
| The Fifth People’s Hospital of Shenzhen City， Shenzhen 518000， China |
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Abstract Objective： To investigate the effect and possible mechanism of lanthanum carbonate on vascular calcification in dialysis patients. Method： 30 regular hemodialysis patients（ dialysis for at least 3 months） admitted to our hospital from January 2013 to August 2014 as the research objects， and were given the lanthanum carbonate treatment for 12 weeks， to compare iPTH（ serum intact parathyroid hormone）， FGF23（ fibroblast growth factor 23）， 25（OH）D（ serum 25 hydroxy vitamin D） and other indicators level before and after treatment of patients. In addition， to take calcium carbonate for 1 month after disable lanthanum carbonate， and compare the index level of the two groups. Result： The serum phosphate before and after lanthanum carbonate treatment between the two groups，the difference was statistically significant（ P<0.05）. In addition， lanthanum carbonate， calcium carbonate treatment for 1 month after the patients blood phosphorus，the differences were significant（ P<0.05）. In addition， the incidence of adverse reactions was 20.00%
during the lanthanum carbonate treatment. Conclusion： Lanthanum carbonate has an important role in the treatment of dialysis patients with hyperphosphatemia， prevent to vascular calcification， and lanthanum carbonate may be through the reduction of FGF23 and blood phosphorus level to achieve the purpose of prevention of vascular calcification.
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