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Abstract Objective：To investigate the clinical effect of total gastrectomy and radical resection of proximal gastric cancer in patients with advanced proximal gastric carcinoma.Method：The clinical data of 170 patients with advanced proximal gastric cancer in our hospital from July 2005 to July 2010 were retrospectively analyzed.Among them 80 patients（total gastrectomy group） were given total gastrectomy，the other 90 patients（radical resection group） were given radical resection of proximal gastric cancer.The survival rates of 28-day and 5-year after the operation，the intraoperative indexes，the health economics indexes and the occurrence of postoperative complications were investigated and compared between the two groups.Result：The differences in the 28-day survival rate，5-year survival rate，number of lymph node dissection，total length of hospital stay，total cost and occurrence rates of postoperative complications of the two groups were not statistically significant（P>0.05）.The operative time，intraoperative bleeding volume and the length of stay in ICU of the radical resection group were less than those of the total gastrectomy group，the differences were statistically significant（P<0.05）.Conclusion：Radical resection of proximal gastric cancer has no effect on survival rate of advanced proximal gastric carcinoma.It is better than total gastrectomy in the aspects of operative time，intraoperative bleeding volume and the length of stay in ICU.
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