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| Effect of Norepinephrine and Dopamine in the pH Value of Gastric Mucosa in Patiens with Septic Shock |
| Xinhua Hospital of Hubei Province，Wuhan 430015，China |
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Abstract Objective：To investigate the effect of Norepinephrine and Dopamine in the pH value of gastric mucosa in patients with septic shock.Method：64 patients with septic shock were selected and divided into Norepinephrine treatment group（group A） and Dopamine treatment group（group B），32 cases in each group.The change of hemodynamic index before and after medication 6 hours and the pH value of gastric mucosa before and after medication 6，12，24 and 48 hours were observed.Result：Before medication，the hemodynamic index and the pH value of gastric mucosa of two groups had no significant differences（P>0.05）.After treatment，mean arterial pressure（MAP） of two groups significantly improved，but the difference was no statistically significant（P>0.05）. The central venous pressure（CVP）and central venous oxygen saturation（ScvO2） of two groups were significantly improved and group A was higher than group B，heart rate of group B increased significantly than group A，the differences were statistically significant（P<0.05）.The pH value of gastric mucosa after medication 6，12，24，and 48 hours in group A were significantly improved than before medication， the differences were statistically significant（P<0.05），there was no significant change of that in group B（P>0.05）.Conclusion：Norepinephrine and Dopamine can all improve the whole body hemodynamic state in patients with septic shock，but Norepinephrine is better than Dopamine，Norepinephrine can improve the pH value of gastric mucosa than Dopamine.
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