|
Abstract Objective：To investigate the effects of inhaled Tiotropium on pulmonary function results in patientswith stable chronic obstructive pulmonary disease（COPD）.Method：68 COPD patients were randomly divided intoexperimental group（tiotropium group） and control group.The pulmonary functio（FEVlFEVl/FVC，FEVl%） andinfiammatory cytokines（IL-8，TNF-α） were measured both before and 6 weeks after inhalation.Result：（1）Therewere no significant differences in the values of forced expiratory volume in FEV1，FEV1/FVC，FEV1%，IL-8 andTNF-α before treatment between two groups（ P>0.05）.（2）These were significantly improved in the values of forcedexpiratory volume in FEV1， FEV1/FVC，FEV1%（P<0.01 or P<0.05），the levels of IL-8，TNF-αin induced sputumcan be significantly decreased between two groups（P<0.01），and after treatment the experimental group were better thanthe control grou（P<0.01）.Conclusion：Inhaled tiotropium can significantly improve the pulmonary functions，reducethe levels of inflammatory cytokines and airway inflammation in the treatment of COPD patients at stable stage.
|
|
|
|
|
|
