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Abstract Objective: To study the value of CT quantitative analysis in differentiating different pathological subtypes of pulmonary sub-solid adenocarcinoma. Method: From January 2020 to June 2022, 57 patients with sub-solid lung adenocarcinoma in Hai'an Hospital of Traditional Chinese Medicine were selected and divided into invasive adenocarcinoma cancer (IAC) and non-invasive adenocarcinoma cancer (n-IAC) according to their pathological subtypes. The clinical characteristics and CT quantitative analysis parameters of IAC patients and n-IAC patients were compared. The value of CT quantitative parameters in the differential diagnosis of pathological subtypes of sub-solid lung adenocarcinoma was analyzed by using the receiver operating characteristic (ROC) curve. Result: There were no significant differences in gender, age, nodule location, smoking history and family history between IAC patients and n-IAC patients (P>0.05); the diameter of nodules, the proportion of stage Ⅲ-Ⅳ, the proportion of poorly differentiated and the proportion of lymph node metastasis in IAC patients were all larger than those in n-IAC patients (P<0.05); the total nodule volume, solid component volume, three-dimensional average CT value, solid component volume ratio, total nodule mass, solid component mass and solid component mass ratio of IAC patients were all greater than those of n-IAC patients (P<0.05); ROC analysis showed that the cut-off value of solid component volume ratio and solid component mass ratio in differentiating pathological subtypes of lung sub-solid lung adenocarcinoma were 24.59%, 28.74%, AUC were 0.865, 0.928, sensitivity were 84.85%, 93.94%, specificity were 87.50%, 79.17%. Conclusion: CT quantitative analysis has a high value in differential diagnosis of pathological subtypes of pulmonary sub-solid adenocarcinoma.
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Received: 12 October 2022
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