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| Effect of Cinepazide Combined with Fasudil in the Treatment of Cerebral Vasospasm after Cerebral Aneurysm Embolization |
| CUI Bo |
| Jiamusi Central Hospital, Heilongjiang Province, Jiamusi 154002, China |
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Abstract Objective: To study the effect of Cinepazide combined with Fasudil in the treatment of cerebral vasospasm after cerebral aneurysm embolization. Method: A total of 124 patients with cerebral vasospasm after cerebral aneurysm embolization admitted to Jiamusi Central Hospital from June 2020 to June 2022 were selected, they were divided into control group and observation group according to random number table method, with 62 cases in each group. The control group was treated with Fasudil, and the observation group was added with Cinepazide on the basis of control group. The clinical efficacy, neurological function scores, cerebral hemodynamics indexes, brain injury markers and treatment safety were compared between the two groups. Result: The total effective rate of the observation group was 91.94%, which was higher than 77.42% of the control group (P<0.05). After treatment, the NIHSS score of the observation group was lower than that of the control group, and the mini mental state examination scale (MMSE) score of the observation group was higher than that of the control group (P<0.05). After treatment, the maximum peak velocity (MPV), Vmean (Vm) and pulse index (PI) of middle cerebral artery of the observation group were higher than those of control group, and the vascular resistance index (RI) was lower than that of the control group (P<0.05). After treatment, the levels of calmodulin-dependent protein kinase 2 (CAMK2), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and neurofibroin (NF) of the observation group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of Cinepazide and Fasudil has a good effect on cerebral vasospasm after cerebral aneurysm embolization, it can improve the neurological function of patients, increase the cerebral blood flow velocity, inhibit the expression level of brain injury marker protein.
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Received: 09 September 2022
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