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| Effect of Phloroglucinol on HO-1, PIBF Levels and Clinical Symptoms in Patients with Threatened Abortion |
| GUO Liping, CHEN Qiulian, CHEN Lin |
| Xinyu People's Hospital, Jiangxi Province, Xinyu 338000, China |
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Abstract Objective: To observe the effect of Phloroglucinol on heme oxygenase-1 (HO-1), progesterone-inducible blocking factor (PIBF) levels and clinical symptoms in patients with threatened abortion. Method: A total of 84 patients with threatened abortion who were admitted to Xinyu People's Hospital from January 2020 to February 2022 were selected, they were divided into two groups according to the random number table method, with 42 cases in each group. The control group was given Progesterone treatment, on this basis, the observation group was given Phloroglucinol treatment, continuous treatment for 1 week. The therapeutic efficacy, clinical symptom improvement time, sex hormone levels, HO-1, PIBF levels and adverse reactions were compared between the two groups. Result: The total effective rate in the observation group was higher than that in the control group (P<0.05). Compared with the control group, the time of hemostasis, abdominal pain relief and contraction disappearance were shorter in the observation group (P<0.05). After treatment, human chorionic gonadotropin (β-hCG) and progesterone (P) in both groups were higher than those before treatment, and compared with the control group, observation group were higher (P<0.05). After treatment, HO-1 and PIBF in both groups were higher than those before treatment, and compared with control group, the observation group were higher (P<0.05). No serious adverse reactions occurred during the treatment. Conclusion: Phloroglucinol can effectively regulate the levels of HO-1, PIBF and sex hormones in patients with threatened abortion, promote the improvement of clinical symptoms and improve the therapeutic effect.
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Received: 09 October 2022
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